Clinical research of early intervention of modified shuyu pill in vascular cognitive impairment no dementia.
- Author:
Zi-Hu TAN
1
;
Han-Chao LAN
;
Qiong YANG
;
Jun CHEN
;
Shan-Ping MAO
;
Yun-Fei ZHA
;
Sheng-Jun XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Cognition Disorders; prevention & control; Drugs, Chinese Herbal; therapeutic use; Early Medical Intervention; Female; Humans; Indans; therapeutic use; Male; Middle Aged; Piperidines; therapeutic use
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(1):27-30
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe early intervention effects of Modified Shuyu Pill (MSP) on vascular cognitive impairment no dementia (VCIND).
METHODSTotally 100 patients VCIND were randomly assigned to the treatment group (43 cases) and the control group (33 cases). On the basis of the treatment targeting risk factors of blood vessels, patients in the treatment group were treated by MSP, while those in the control group were treated by donepezil hydrochloride. The therapeutic course was 16 weeks. The neuropsychological scales [mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) score] and Chinese medicine dementia syndromes scales were observed before and after treatment.
RESULTSThe MMSE and MOCA score of the two groups increased when compared with the same group before treatment (P < 0.01). But there was no statistical difference in MMSE or MOCA score after treatment between the two groups (P > 0.05). The Chinese medicine dementia syndromes scales significantly decreased in the treatment group when compared with before treatment (P < 0.01). But there was no statistical difference in Chinese medicine dementia syndromes scales in the control group between before and after treatment (P > 0.05). There was statistical difference in Chinese medicine dementia syndromes scales after treatment between the two groups (P < 0.01).
CONCLUSIONMSP could effectively intervene the progress of VCIND.
