Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice.
- Author:
Yunsook LIM
1
;
Maret G TRABER
Author Information
- Publication Type:Other
- Keywords: alpha-tocopherol; alpha-tocopherol transfer protein; vitamin E
- MeSH: alpha-Tocopherol*; Animals; Cytosol; Humans; Infertility; Lipoproteins; Liver; Metabolism; Mice; Mice, Knockout*; Muscle Weakness; Nervous System Diseases; Plasma; Vitamin E; Vitamin E Deficiency; Vitamins
- From:Nutrition Research and Practice 2007;1(4):247-253
- CountryRepublic of Korea
- Language:English
- Abstract: Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. Genetic defects in alpha-TTP, like dietary vitamin E deficiency, are associated with infertility, muscular weakness and neurological disorders. Both human and alpha-TTP deficient (alpha-TTP-/-) mice exhibit severe plasma and tissue vitamin E deficiency that can be attenuated by sufficient dietary alpha-T supplementations. In this review, we summarize the literature concerning studies utilizing the alpha-TTP-/- mice. Levels of vitamin E in the alpha-TTP-/- mice do not appear to be directly related to the amounts of dietary alpha-T or to the levels of alpha-TTP protein in tissues. The alpha-TTP-/- mice appear to present a good model for investigating the specific role of alpha-T in tissue vitamin E metabolism. Furthermore, alpha-TTP-/- mice appear to be useful to elucidate functions of alpha-TTP beyond its well recognized functions of transferring alpha-T from liver to plasma lipoprotein fractions.
