In vitro study of platelet glycoprotein monoclonal antibody eluting stents.
- Author:
Lai-long LUO
1
;
Gui-xue WANG
;
Tie-ying YIN
;
Shi-sui LUO
;
Chang-gen RUAN
;
Yan-bin HOU
Author Information
1. Bioengineering College of Chongqing University.
- Publication Type:Journal Article
- MeSH:
Absorption;
Alloys;
chemistry;
Antibodies, Monoclonal;
chemistry;
immunology;
Drug-Eluting Stents;
Graft Occlusion, Vascular;
immunology;
prevention & control;
Humans;
Lactic Acid;
chemistry;
Platelet Aggregation Inhibitors;
chemistry;
immunology;
Platelet Glycoprotein GPIIb-IIIa Complex;
immunology;
Polymers;
analysis;
chemistry;
Time Factors
- From:
Chinese Journal of Medical Instrumentation
2006;30(3):163-166
- CountryChina
- Language:Chinese
-
Abstract:
In order to prove the feasibility of preparation of the drug-incorporated stent by immersing stent wires in the monoclonal antibody (mAb) solution, fluorescence stain and image analysis were used to evaluate the L-PLA-coated stent. Absorption was measured using a radioisotope technique after preparing the mAb-incorporated stent, and the absorption curve was determined from the absorption data. In an in vitro perfusion circuit, the antibody was eluted from the stent matrices, and the related influence factors were evaluated based on the release data.
