Expression of helicase DDX41 in human dental pulp tissues and cells.
- Author:
Xiao-Jun YANG
1
;
Jin HOU
;
Xin-Zhu LI
;
Jiao HU
Author Information
- Publication Type:Journal Article
- MeSH: Cell Nucleus; metabolism; Cells, Cultured; Cytoplasm; metabolism; DEAD-box RNA Helicases; metabolism; Dental Pulp; metabolism; Humans; Immunohistochemistry; Odontoblasts; metabolism; RNA, Messenger; Signal Transduction
- From: Journal of Southern Medical University 2015;35(4):587-590
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells.
METHODSThe mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry.
RESULTSStrong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts.
CONCLUSIONDDX41/STING-dependent TBK1-IRF3-IFN-β signaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.
