Omics of vector mosquitoes: a big data platform for vector biology and vector-borne diseases.
- Author:
Yang WU
1
;
Lihua XIE
;
Peiwen LIU
;
Xiaocong LI
;
Guiyun YAN
;
Xiaoguang CHEN
Author Information
1. Key Laboratory of Prevention and Control for Emerging Infectious Diseases of Guangdong Higher Institutes, Department of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China.E-mail: youngwoo@vip.qq.com.
- Publication Type:Journal Article
- MeSH:
Aedes;
genetics;
Animals;
Anopheles;
genetics;
Culex;
genetics;
Gene Expression Profiling;
Genome, Insect;
Genomics;
High-Throughput Nucleotide Sequencing;
MicroRNAs
- From:
Journal of Southern Medical University
2015;35(5):625-630
- CountryChina
- Language:Chinese
-
Abstract:
Recently the studies on mosquito genomics, transcriptomics and small RNAomics developed rapidly with the novel biotechnologies of the next generation sequencing techniques. The genome sequences of several important vector mosquitoes including Anopheles gambiae, Culex quinquefasciatus, and Aedes aegypti have been published. The genome sizes vary among the different species of mosquitoes and are consistent with the number of the repeat regions. The released genome sequences facilitate gene cloning and identification as for OBP, OR and dsx genes. Transcriptomics provides a useful tool for functional analyses of the mosquito genes, and using this technique, the molecular basis of mosquito blooding, gland proteins and diapauses have been explored. Studies on small RNAomics suggest important roles of miRNAs and piRNAs in ovary development, blood digestion, and immunity against virus infection. The studies on mosquito omics have generated a big data platform for investigation of vector biology and vector-transmitted disease prevention.
