Effect of Radix euphorbiae pekinensis extract on bioavailability of paclitaxel after their oral co-administration.
- Author:
Minghua LI
1
;
Li PENG
;
Fuheng YANG
;
Sijia LIU
;
Shengqi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Biological Availability; Biological Transport; Chromatography, High Pressure Liquid; Euphorbiaceae; chemistry; Paclitaxel; pharmacokinetics; Permeability; Plant Extracts; pharmacology; Plant Roots; chemistry; Rats; Tandem Mass Spectrometry; Verapamil
- From: Journal of Southern Medical University 2015;35(6):916-921
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of Radix euphorbiae pekinensis extract on the permeability and bioavailability of paclitaxel co-administered orally.
METHODSBased on Ussing Chamber and in vivo experiment, the permeability and bioavailability of paclitaxel were evaluated after oral co-administration with radix euphorbiae pekinensis in rats. The contents of paclitaxel in the permeates and the blood samples were determined using HPLC and LC-MS/MS method, respectively.
RESULTSIn Radix euphorbiae pekinensis co-administration group, the Papp of the mucosal-to-serosal (M-S) transport or serosal-to-mucosal transport (S-M) of paclitaxel in the jejunum or ileum segment differed significantly from those in verapamil co-administration group and blank control group (P<0.05), but the Papp of S-M transport in the colon showed no significant difference from that in the blank control group. In the blank group, the average absolute bioavailability (AB%) of orally administered paclitaxel was only 2.81%, compared to that of 7.63% in radix euphorbiae pekinensis group. The average AB% in verapamil group was about 1.5 times that of the blank group.
CONCLUSIONCo-administration of Radix euphorbiae pekinensis extract can increase the bioavailability of orally administered paclitaxel.
