Expression of P53 and Bax in rat liver induced by microcystin LR in vivo.
- Author:
Xiu-min WANG
1
;
Jia-ping CHEN
;
Wen-yu FU
;
Li-hong XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; Bacterial Toxins; toxicity; Liver; metabolism; pathology; Male; Marine Toxins; toxicity; Microcystins; Peptides, Cyclic; toxicity; Proto-Oncogene Proteins c-bcl-2; biosynthesis; genetics; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53; biosynthesis; genetics; bcl-2-Associated X Protein
- From: Journal of Zhejiang University. Medical sciences 2005;34(3):220-222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the expression of P53, Bcl-2 and Bax proteins in rat liver after exposed to microcystin LR.
METHODSSD rats received microsystin LR by gastric perfusion. The expression of P53, Bax and Bcl-2 in liver was detected by Western blot.
RESULTSThe expression of P53 and Bax in each treatment group increased significantly compared with that in control group(P<0.05), with the exception of 0.1 microg/kg LR exposure group. Moreover, with exposure levels increasing the expression of P53 and Bax increased gradually; while no changes of the expression of Bcl-2 were observed.
CONCLUSIONP53 and Bax may play important roles in microcystin LR induced apoptosis, but Bcl-2 seems not be involved in this process.
