Determination of interleukine-16 levels in peritoneal fluid and serum of women with endometriosis.
- Author:
Jun LIN
1
;
Xin-mei ZHANG
;
Lin DENG
;
Zheng-yun CHEN
;
Li CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Ascitic Fluid; chemistry; Endometriosis; metabolism; Female; Humans; Interleukin-16; analysis; blood; Middle Aged
- From: Journal of Zhejiang University. Medical sciences 2005;34(3):260-262
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of interleukine-16 (IL-16) in the pathogenesis of endometriosis.
METHODSEnzyme-linked immunosorbent assay (ELISA) was used to determine the levels of IL-16 in peritoneal fluid and serum specimens of 22 women with different stage endometriosis and 22 controls.
RESULTSThe median levels of IL-16 in peritoneal fluid and serum were 290.5 pg/ml and 539.4 pg/ml in women with endometriosis, and 296.6 pg/ml and 778.1 pg/ml in controls, respectively; there was no significant difference between two groups (P>0.05). However, the IL-16 levels in peritoneal fluid and serum of patients with minimal/mild stage endometriosis and controls were all significantly higher than those of patients with moderate/severe endometriosis (P<0.01, <0.05). In addition, there was no statistical correlation of peritoneal IL-16 levels with those in serum (P>0.05).
CONCLUSIONReduced levels of IL-16 in peritoneal fluid and serum of women with advanced stage endometriosis may imply a role of IL-16 in the development and progression of endometriosis.
