Hearing screening in infants with congenital cytomegalovirus infection.
- Author:
Wei MO
1
;
Yi-ying ZHANG
;
Yun-qiu LEI
;
Wei SUN
;
Pei-fen SHAO
;
Yue-feng SUN
;
Yuan-yuan ZHOU
;
Zheng-yan ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Cytomegalovirus Infections; complications; congenital; physiopathology; Evoked Potentials, Auditory, Brain Stem; Female; Follow-Up Studies; Hearing Loss, Bilateral; epidemiology; prevention & control; Humans; Infant, Newborn; Male; Neonatal Screening; Otoacoustic Emissions, Spontaneous
- From: Journal of Zhejiang University. Medical sciences 2005;34(4):358-360
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the impact of congenital cytomegalovirus infection on the hearing ability in infants.
METHODSBy using the tools of distortion product otoacoustic emission (DPOAE) and auditory brain-stem response (ABR), the hearing ability of 38 infants with congenital cytomegalovirus infection and 16 cases of normal controls during neonatal periods was screened with a follow-up study at 6 and 24 months.
RESULTIn infants with congenital cytomegalovirus infection, 86.8% (66/76) ears at neonatal stage and 76.3% (58/76) ears at 6 months passed the tests; while in normal controls, 96.9% (31/32) ears passed the tests. The reaction threshold of ABR V in infants with congenital cytomegalovirus infection was higher than that in normal controls (P<0.005). Furthermore,in infants with congenital cytomegalovirus infection, 13 ears (17.1%) were extreme hearing loss, 5 ears (6.6%) were severe hearing loss, and 6 ears (7.9%) were moderately severe hearing loss. The incidence of hearing loss during the follow-up was 7.9% (3/38) at neonatal stage, 23.7% (9/38) at 3-4 months, and 7.9% (3/38) after 6 months.
CONCLUSIONThe congenital cytomegalovirus infection could cause the prompt and late-onset hearing loss. The combination of the laboratory evidence with the dynamic hearing screening may contribute to the early detection of hearing loss in infants with congenital cytomegalovirus infection.
