Study on determination of desloratadine in human serum and its pharmacokinetics by HPLC/MS.
- Author:
Xiao-yang LU
1
;
Jian-zhong SHENG-TU
;
Zhi-gen CHEN
;
Ming-zhu HUANG
;
Hui-li ZHOU
;
Guo-gang ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, High Pressure Liquid; methods; Histamine H1 Antagonists, Non-Sedating; blood; pharmacokinetics; Humans; Loratadine; analogs & derivatives; blood; pharmacokinetics; Mass Spectrometry; methods
- From: Journal of Zhejiang University. Medical sciences 2005;34(4):372-374
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the determination of desloratadine in human serum and its pharmacokinetics in healthy volunteers.
METHODSA single oral dose of 10 mg desloratadine was given to 18 healthy volunteers. The serum concentrations of desloratadine were determined by HPLC-MS assay. The pharmacokinetics parameters of desloratadine tablets were calculated with program 3P97.
RESULTThe main pharmacokinetics parameters of desloratadine tablets were as followsút(max)(1.611 +/-0.366)h, C(max) (4.455+/-1.990)microg x L(-1), AUC(0-t) (58.50+/-21.34)microg x L(-1) x h(-1), AUC(0-infinity) (60.59+/-22.32)microg x L(-1) x h(-1), t(1/2(ke)) (20.303+/-5.833)h, Ke (0.0372+/-0.0116)h(-1) and CL(0.1838+/-0.0563)L x h(-1).
CONCLUSIONDesloratadine tablet is absorbed quicker in the 18 healthy volunteers than the reports and its peak blood concentration reached at 1.5 h after oral administration with t(1/2) 20 h.
