Expression of MMP-2 and E-CD in salivary mucoepidermoid carcinoma and its correlation with infiltration, metastasis and prognosis.
- Author:
Ji-an HU
1
;
Jing-yao XU
;
Yi-ning LI
;
Song-ying LI
;
Hong YING
Author Information
- Publication Type:Journal Article
- MeSH: Cadherins; biosynthesis; genetics; Carcinoma, Mucoepidermoid; metabolism; pathology; Humans; Matrix Metalloproteinase 2; biosynthesis; genetics; Neoplasm Invasiveness; Neoplasm Metastasis; Prognosis; Salivary Gland Neoplasms; metabolism; pathology
- From: Journal of Zhejiang University. Medical sciences 2005;34(5):421-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expressions of matrix metalloproteinase 2 (MMP2) and E-cadherin (E-CD) in salivary mucoepidermoid carcinoma, and their relationship with clinical stages, pathological grading, lymph node metastasis and prognosis.
METHODSSurgical specimens of salivary mucoepidermiod carcinoma and normal salivary gland tissue were collected. MMP-2 and E-CD were stained immunohistochemically with streptavidin peroxidase method.
RESULTSThe expression of MMP-2 was increased and the expression of E-CD was reduced or negative in salivary mucoepidemoid carcinoma compared with those of the normal salivary gland. Expression of MMP-2 and E-CD was closely correlated with lymph node metastasis of the mucoepidermoid carcinoma. MMP-2 was positively correlated with the prognosis of mucoepidermoid carcinoma, and E-CD was negatively correlated to the prognosis of mucoepidermoid carcinoma.
CONCLUSIONThe expression of MMP-2 and E-CD is closely correlated with the metastasis and prognosis of salivary mucoepidermoid carcinoma.
