Relationship between serum and placental interleukin-18 levels and preeclampsia.
- Author:
Xia-di HUANG
1
;
He-feng HUANG
;
Min-yue DONG
;
Qi-wei YAO
;
Hang-zhi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-18; blood; metabolism; Placenta; metabolism; Pre-Eclampsia; metabolism; Pregnancy
- From: Journal of Zhejiang University. Medical sciences 2005;34(6):495-498
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of interleukin (IL)-18 concentrations in serum and placenta and preeclampsia.
METHODSTwenty-seven patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placenta samples were taken and serum and placental IL-18 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). The levels of IL-18 in serum and placenta were compared.
RESULT(1) The median of serum IL-18 in patients with preeclampsia was 704 ng/L, which was significantly higher than that of control group (470 ng/L, P<0.05). (2) The median of placental IL-18 in patients with preeclampsia was 105 ng/L, which was also significantly higher than that of control group (31.5 ng/L, P<0.005).
CONCLUSIONIncreased serum and placental levels of IL-18 were presented in preeclampsia as compared to normal pregnancy, which might offer insight into the pathogenesis of the disease.
