Relationship between serum resistin level and preeclampsia.
- Author:
Dan-qing CHEN
1
;
Zheng SHI
;
Min-yue DONG
;
Qin FANG
;
Jing HE
;
Zheng-ping WANG
;
Xiao-fu YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Glucose Tolerance Test; Humans; Pre-Eclampsia; blood; Pregnancy; Pregnancy Trimester, Third; blood; Resistin; blood
- From: Journal of Zhejiang University. Medical sciences 2005;34(6):503-528
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the alteration of serum resistin levels in normal pregnancy and preeclampsia.
METHODSBlood samples were take from 28 normal non-pregnant women, 27 women in the 1st, 26 in the 2nd and 26 in the 3rd trimester of normal pregnancy and 25 women with preeclampsia. Serum resistin concentration was determined using ELISA method.
RESULTSerum levels of resistin were not significantly different among non-pregnancy, the 1st and the 2nd trimester of pregnancy (P>0.05 for all). Serum resistin level was significantly elevated in the 3rd trimester of pregnancy as compared with non-pregnancy (P<0.01), the 1st (P<0.001) and the 2nd trimester of pregnancy (P<0.001). Serum resistin level was significantly lower in preeclampsia than in the 3rd trimester of normal pregnancy (P<0.001), but was comparable to that of non-pregnancy, the 1st and the 2nd trimester of pregnancy (P>0.05 for all).
CONCLUSIONThe decrease of serum resistin level in the preeclampsia may provide insight into the pathogenesis of the disease.
