Effect of acute coronary microembolization on microvascular injury and myocardial endothelin-1 levels.
- Author:
Qing-yong ZHANG
1
;
Jun-bo GE
;
Jian-hua ZHU
;
Qing-gang ZHANG
;
Liang-hui ZHANG
;
Ju-ying QIAN
;
Jun-zhu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Coronary Vessels; pathology; Disease Models, Animal; Embolism; Endothelin-1; blood; Female; Male; Myocardial Infarction; blood; pathology; Swine; Swine, Miniature
- From: Journal of Zhejiang University. Medical sciences 2005;34(6):538-546
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of coronary microemboliation (CME) on coronary microvascular injury and myocardial endothelin-1 (ET-1) level.
METHODSCME was induced in 10 miniswines by selective infusion of microspheres (45 microm) into left anterior descending artery (LAD). The ET-1 level in coronary sinus was measured with radioimmunoassay. The microvascular integrity indicator CFR was measured by Doppler flow wire in LAD at baseline and after infusion of microspheres.
RESULTCompared to the baseline, CFR decreased significantly with different doses of microspheres. ET-1 level increased significantly with doses of 5 x 10(4) and peaked with 10 x 10(4), and progressively decreased from doses of 12 x 10(4) to 15 x 10(4) microspheres. There was negative correlation between ET-1 and CFR (r=-0.31, P=0.02).
CONCLUSIONThe extent of microvascular injury is not linearly related to the extent of microembolization, but it is closely associated with myocardial ET-1 level.
