Significance of serum CD62p and CD63 levels in patients with head injury.
- Author:
Hua-bo CAI
1
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Antigens, CD; blood; Blood Platelets; metabolism; Brain Injuries; blood; Female; Humans; Male; Middle Aged; P-Selectin; blood; Platelet Activation; Platelet Membrane Glycoproteins; Tetraspanin 30; Trauma Severity Indices
- From: Journal of Zhejiang University. Medical sciences 2005;34(6):562-565
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the serum levels of CD62p (alpha-granular membrane protein) and CD63 (lysosome intact membrane protein) in patients with head injury and to observe its relation to injury severity.
METHODSFifty-three patients with head injury were divided into 3 groups; Group A patients with mild head injury; Group B with moderate head injury; and Group C with severe head injury. The serum levels of CD62p, CD63 were measured on 12 h, d 1, 3, 5 and 7 after injury.
RESULTThe serum levels of CD62p and CD63 in Group B and Group C were higher than those in Group A and control (P<0.05). The serum level of CD62p in Group C was higher than that in Group B (P<0.05). The serum levels of CD62p in Group C on d 1, 3, 5 after injury were higher than those on 12 h (P<0.05). The serum level of CD63 in Group B on d 3 after injury were higher than that on 12 h (P<0.05). The serum levels of CD63 in Group C on d 1, 3, 5 after injury were higher than those on 12 h (P<0.05).
CONCLUSIONThe serum levels of CD62p and CD63 in patients with head injury may be helpful for identifying the severity of injury, and CD62p seems to be more sensitive.
