Immune status of BALB/c mice and rubella virus JR23 strain infection of central nervous system.
- Author:
Zhiyu WANG
1
;
Ping YAO
;
Yanyan SONG
;
Hongzhi XU
;
Guiting WANG
;
Yanxun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibody Specificity; Central Nervous System Infections; immunology; virology; Female; Immunity, Cellular; Male; Mice; Mice, Inbred BALB C; Rubella; immunology; Rubella virus; immunology; T-Lymphocytes; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2002;16(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo investigate the relationship between immune status and rubella virus (RV) infection of central nervous system (CNS).
METHODSBALB/c mice were given dexamethaxone and cytoxan before RV JR23 strain infection. Immune functions and RV invasion to CNS were assayed at 21 days postinfection via abdominal cavity and their relationship was analyzed.
RESULTST cell functions of cytoxan group were obviously worse than those of other groups (P <0.05) by MTT method. Infection rates of dexamethaxone and cytoxan and the group without any intervention were 60%, 90% and 50% (P >0.05), respectively. Cellular immune functions of the mice with CNS infection were obviously worse than those of the mice without CNS infection (P <0.001). Specific antibodies (Ab) were assayed in all groups with ELISA and the results showed that there were no significant differences among groups (P >0.05), neither between the groups with and without CNS infections.
CONCLUSIONSRV infection of CNS may relate to cellular immune status before specific antibody was produced in the body.
