Effect of bilirubin derivative on HIV-1 in vitro.
- Author:
Yao YE
1
;
Qi WANG
;
Guomin CHEN
;
Yi ZHANG
;
Fang YAN
;
Tianyu WANG
;
Jinshi MA
;
Zelin LI
;
Yi ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Anti-HIV Agents; pharmacology; Bilirubin; analogs & derivatives; pharmacology; Dose-Response Relationship, Drug; HIV-1; drug effects; Humans; In Vitro Techniques
- From: Chinese Journal of Experimental and Clinical Virology 2002;16(1):66-68
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo study the effect of DTB against HIV-1, for developing anti-HIV drugs.
METHODSDifferent concentration of DTB was added to cell culture system after viral inoculation, MTT staining method for viable cells (MTT assay) and p24 (ELISA) were used as markers to monitor the viral replication.
RESULTSThe inhibition rates of DTB at concentrations 160, 80, and 40mg/ml were 93.0%, 56.2% and 18.1%, respectively.
CONCLUSIONSDTB could effectively inhibit HIV-1 in vitro.
