Autologous skeletal myoblast transplantation improves hemodynamics dogs with chronic heart failure dogs.
- Author:
Dong-yun LI
1
;
Li FAN
;
Kun-lun HE
;
Hong-biin LIU
;
Ming FAN
;
Shu-hong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chronic Disease; Dogs; Female; Heart Failure; physiopathology; therapy; Hemodynamics; Male; Myoblasts, Skeletal; transplantation; Transplantation, Autologous
- From: Journal of Southern Medical University 2010;30(3):475-477
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo test the effects of autologous skeletal myoblast transplantation on the hemodynamics in dogs with coronary microembolization-induced chronic heart failure (CHF).
METHODSCHF models were successfully induced in 19 dogs and divided into ASMT group (n=9) and control group (n=10). The myoblasts were injected into the embolized region in the 9 dogs of the ASMT group, and saline was injected in the control dogs, and the hemodynamics of the dogs were evaluated 5 weeks after the injections.
RESULTCompared with saline injection, ASMT significantly increased dP/dtmax, MAP and LVSP (P<0.05) and decreased LVEDP (P<0.05) 5 weeks after myoblast transplantation. Desmin and Brd-U immunofluorescent staining showed myoblast survival at the injected sites in the dogs.
CONCLUSIONASMT provides mild improvements in the hemodynamics of dogs with CHF.
