Pharmacokinetics and pharmacodynamics of poly (lactide-co-glycolide) microspheres containing ropivacaine and dexamethasone for sciatic nerve block in mice.
- Author:
Rang-hui YU
1
;
Zhong-qing CHEN
;
Hui CHEN
;
Wei-jun FU
;
Yan XU
Author Information
- Publication Type:Journal Article
- MeSH: Amides; pharmacokinetics; pharmacology; Anesthetics, Local; pharmacokinetics; pharmacology; Animals; Delayed-Action Preparations; Dexamethasone; pharmacokinetics; pharmacology; Female; Lactic Acid; chemistry; Mice; Microspheres; Nerve Block; methods; Polyglycolic Acid; chemistry; Random Allocation; Sciatic Nerve
- From: Journal of Southern Medical University 2010;30(3):502-505
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the pharmacokinetics and pharmacodynamics of poly (lactide-co-glycolide) microspheres containing ropivacaine and dexamethasone for sciatic nerve block in mice.
METHODSA total of 165 female mice were randomly assigned into 3 groups, namely dexamethasone-loaded ropivacaine microsphere group (group A, n=55), ropivacaine microsphere group (group B, n=55) and PLGA microsphere group (group C, n=55). The mice received surgical implantation of the corresponding preparations near the sciatic nerve at the dose of 400 mg/kg. Hot plate test was used to evaluate the anesthetic effect of these microspheres at different time points after the implantation, and high-performance liquid chromatography (HPLC) was employed to determine plasma ropivacaine concentration.
RESULTSPharmacodynamic study showed that the duration of sciatic nerve sensory block was significantly longer in group A than in group B (P<0.05). The analysis of pharmacokinetics variables demonstrated that T(1/2) in group A was prolonged as compared with that of group B. No anesthetic effect was observed in group C.
CONCLUSIONDexamethasone-loaded ropivacaine microspheres can significantly prolong the analgesic effect of ropivacaine in mice.
