Relationship between clinical stages of nasopharyngeal carcinoma and Epstein-Barr virus antibodies Rta/IgG, EBNA1/IgA, VCA/IgA and EA/IgA.
- Author:
Yong-lin CAI
1
;
Yu-ming ZHENG
;
Ji-ru CHENG
;
Wei WANG
;
Yi-ni ZHANG
;
Wei-hua WANG
;
Ying-song WU
;
Wei-ming ZHONG
;
Jun LI
;
Yong-kun MO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Antibodies, Viral; blood; immunology; Antigens, Viral; immunology; Capsid Proteins; immunology; Epstein-Barr Virus Nuclear Antigens; immunology; Female; Herpesvirus 4, Human; immunology; Humans; Immediate-Early Proteins; immunology; Immunoglobulin A; blood; Immunoglobulin G; blood; Male; Middle Aged; Nasopharyngeal Neoplasms; immunology; pathology; virology; Neoplasm Staging; Trans-Activators; immunology; Young Adult
- From: Journal of Southern Medical University 2010;30(3):509-511
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between the clinical stages of nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV) antibodies Rta/IgG, EBNA1/IgA, VCA/IgA and EA/IgA.
METHODSSerum samples obtained from 211 untreated patients with NPC categorized by the project of 92' stage were examined for the presence of the EBV antibodies Rta/IgG and EBNA1/IgA by enzyme-linked immnunosorbent assay (ELISA) and for VCA/IgA and EA/IgA by immunoenzymatic assay. The positive rates and antibody levels in the NPC patients in different TNM stages and clinical stages were analyzed statistically.
RESULTSNo significant difference in Rta/IgG rA value was found in the NPC patients in different TNM or clinical stages (P>0.05). The EBNA1/IgA rA value was significantly lower in stage T1, N0, and clinical stage I than in the other corresponding T stages, N stages and other clinical stage (P<0.05). The antibody titers of VCA/IgA and EA/IgA differed significantly between the N stages and the clinical stages (P<0.05).
CONCLUSIONThe expression of EBV Rta/IgG is not associated with NPC stage. The expression of EBNA1/IgA is relatively low in early NPC. The antibody level of VCA/IgA and EA/IgA are significantly correlated to the degree of neck lymph node metastasis, and might be helpful to classify the clinical stages of NPC.
