Expression of chromogranin A in human mammary tissues.
- Author:
Ying-xin CHEN
1
;
Lian-hong LI
;
Jie SUN
;
Bo WANG
;
Li-xia WANG
Author Information
- Publication Type:Journal Article
- MeSH: Breast; metabolism; Breast Neoplasms; metabolism; Carcinoma, Neuroendocrine; etiology; metabolism; Chromogranin A; metabolism; Female; Humans
- From: Journal of Southern Medical University 2010;30(3):547-551
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the pathogenesis and significance of neuroendocrine breast carcinoma by detecting chromogranin A (CgA) in human mammary tissues.
METHODEighty-nine cases of human mammary tissues were collected to detect CgA expression using immunohistochemistry.
RESULTNo CgA expression was detected in normal or hyperplastic tissues, but its expression was found in mammary carcinoma tissues at the rate of 16.7%. A significant difference in CgA expression was found between cancer tissues and non-cancer tissues, but not between the cancer tissues with different pathological grades.
CONCLUSIONThe pathogenesis of mammary neuroendocrine carcinoma may involve the micro-environmental factors that affect the differentiation of stem cells to give rise to immature cells, cell differentiation in other lineages or transdifferentiation. CgA may serve as an immunological parameter for this type of breast cancer in routine screening test.
