Association of cytochrome P4502D6 gene polymorphism with the susceptibility of heroin spongiform leucoencephalopathy.
- Author:
Liang ZHOU
1
;
Bing-xun LU
;
Ja YIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Canavan Disease; chemically induced; genetics; Cytochrome P-450 CYP2D6; genetics; Female; Heroin; adverse effects; Heroin Dependence; complications; Humans; Male; Middle Aged; Mutation; Polymorphism, Restriction Fragment Length; Young Adult
- From: Journal of Southern Medical University 2010;30(3):572-583
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo elucidate the relation between cytochrome P4502D6 (CYP2D6) gene polymorphism and the susceptibility of heroin spongiform leucoencephalopathy (HSLE).
METHODSWith polymerase chain reaction-restriction fragment length polymorphism technique, the cytochrome P4502D6 gene polymorphisms were analyzed in HSLE cases and control subjects.
RESULTSThe frequencies of CYP2D6 (CYP2D6/C188, CYP2D6/L2938, CYP2D6/G4268) gene mutations were higher in HSLE patients than in the controls.
CONCLUSIONThe CYP2D6 gene mutation is associated with a high risk of HSLE.
