Effects of rosuvastatin on left ventricular cardiac function, arteriosclerotic plaque and high sensitive C-reactive protein in hypertensive patients with mild LDL-C elevation.
- Author:
Ze-peng LIN
1
;
Zhi-wei ZHANG
;
Rong-kui ZHANG
;
Ping-chun SHU
;
Shi-qin WU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Arteriosclerosis; complications; pathology; C-Reactive Protein; metabolism; Cholesterol, LDL; blood; Female; Fluorobenzenes; therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; therapeutic use; Hyperlipidemias; drug therapy; pathology; physiopathology; Hypertension; drug therapy; pathology; physiopathology; Male; Middle Aged; Pyrimidines; therapeutic use; Rosuvastatin Calcium; Sulfonamides; therapeutic use; Ventricular Function, Left; drug effects
- From: Journal of Southern Medical University 2010;30(3):588-590
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of rosuvastatin on left ventricular cardiac function, arteriosclerotic plaque and high sensitive C-reactive protein (hs-CRP) in hypertensive patients with mild elevation of LDL-C.
METHODSSeventy-nine patients with a SBP of 140-179 mmHg and/or a DBP of 90-109 mmHg and mild elevated LDL-C were treated with rosuvastatin for 12 months (n=40) or not (n=39). The changes of hs-CRP, arteriosclerosis plaque and cardiac function at the end of the 12-months treatment relative to the baseline levels were analyzed.
RESULTSAfter 12 months of treatment, LDL-C was decreased by 33.2% in rosuvastatin group but remained unchanged in patients without rosuvastatin treatment. The left ventricular peak filling rate (LVPFR) increased significantly from 1.85 to 2.59 (P<0.05) and the serum levels of hs-CRP reduced significantly (P<0.05) after rosuvastatin treatment. The size of the plaques reduced significantly after a 12-month rosuvastatin therapy.
CONCLUSIONRosuvastatin therapy on the basis of conventional anti-hypertensive drugs can obviously improve the left ventricular diastolic function and produce favorable effects on arteriosclerotic plaques.
