Expression of cannabinoid receptor 2 in squamous cell carcinoma.
- Author:
Zi-gang ZHAO
1
;
Yuan-yuan LI
;
Jie YANG
;
Heng-jin LI
;
Hua ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; metabolism; Female; Humans; Male; RNA, Messenger; genetics; metabolism; Receptor, Cannabinoid, CB2; genetics; metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin; metabolism; Skin Neoplasms; metabolism
- From: Journal of Southern Medical University 2010;30(3):593-595
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of cannabinoid receptor 2 (CB2) in normal human skin and squamous cell carcinoma and analyze its relation with the tumorigenesis and development of squamous cell carcinoma.
METHODSThe expression of CB2 protein and mRNA levels were detected in normal human skin and squamous cell carcinoma using immunohistochemical staining and RT-PCR.
RESULTSBoth the normal skin and squamous cell carcinoma expressed CB2, which was localized mainly in the basal cell layer and prickle cell layer in human skin with low expressions in the subcutaneous tissue. The expression intensity of CB2 differed significantly between squamous cell carcinoma and normal human skin (P<0.05).
CONCLUSIONSquamous cell carcinoma over-expresses CB2 at both the protein and mRNA levels. High expression of CB2 in squamous cell carcinoma suggests an important role of CB2 in the tumorigenesis and development of squamous cell carcinoma.
