The correlation between the expression of PRL-R and ER/PR in breast cancer.
- Author:
Rong-hui ZHENG
1
;
Xun-xing GUAN
;
Xiu-ping ZHANG
;
Zhen-yu HE
;
Lai-ji HUANG
;
Zhi-wei LIAO
;
Qin TONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; metabolism; Female; Humans; Middle Aged; Receptor, ErbB-2; genetics; metabolism; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Receptors, Prolactin; metabolism
- From: Journal of Southern Medical University 2010;30(3):596-598
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation of prolactin receptor (PRL-R) expression to estrogen receptor (ER) and progesterone receptor (PR) expressions in primary breast cancer.
METHODSFor 130 female patients with breast cancer (median age 46 years), PRL-R expression in the primary tumor was detected by immunohistochemistry, and the correlation between PRL-R and ER/PR expressions was analyzed statistically.
RESULTSPRL-R positivity in the primary tumor was found in 89 of the patients (68.5%), and the positivity rate for PRL-R was positively correlated to ER expression (P<0.05). Further stratification of the patients according to the CerbB-2 status revealed such a correlation only in CerbB-2-positive patients (P<0.05). In the patient cohort, no significant correlation was found in the positivity rate between PRL-R and PR expressions (P>0.05), but in CerbB-2-positive patients, the positivity rate of PRL-R showed a positive correlation to PR expression (P<0.05).
CONCLUSIONThe positive correlations in positivity rate between the PRL-R and ER/PR expressions are found only in CerbB-2 positive patients with breast cancer, and the expressional status of CerbB-2 affects the correlation between PRL-R and ER/PR expression in breast cancer.
