Expression of SOX4 gene and early recurrence of hepatocellular carcinoma: their relationship and the clinical significance.
- Author:
Jiang-hua ZHENG
1
;
Zhi-xiang JIAN
;
Hao-sheng JIN
;
Si-cong CHEN
;
Guan-yi WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; genetics; metabolism; surgery; Female; Humans; Liver Neoplasms; genetics; metabolism; surgery; Male; Middle Aged; Neoplasm Recurrence, Local; genetics; Prognosis; SOXC Transcription Factors; genetics; metabolism
- From: Journal of Southern Medical University 2010;30(4):818-819
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVET To explore the relationship between the expression of SOX4 gene and early recurrence of hepatocellular carcinoma (HCC) after curative resection.
METHODSSOX4 expression was detected immunohistochemically in 60 HCC patients including 30 with and 30 without early recurrence after curative resection, with 30 normal liver specimens as the control.
RESULTSThe expression of SOX4 was significantly higher in HCC than in normal liver (41.7% vs 16.7%, P<0.05), and in HCC tissues, the expression was significantly higher in early recurrent HCC after curative resection than in HCC without early recurrence (56.7% vs 26.7%, P<0.05). SOX4 expression was inversely correlated to the patients' gender, age, tumor size, HBsAg, and Edmonson grade (P<0.05).
CONCLUSIONSOX4 is closely associated with early recurrence of HCC after curative resection, and its overexpression may contribute to early recurrence of HCC. SOX4 may serve as a new molecular indicator for evaluating the prognosis of HCC.
