Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis.
- Author:
Feng-long WANG
1
;
Jian-ming JIANG
;
Fei WANG
;
Zhao-zong FU
;
Zhao-fei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Cells, Cultured; Dinoprostone; metabolism; Female; Humans; Interleukin-18; metabolism; Male; Middle Aged; Osteoarthritis; metabolism; pathology; Synovial Membrane; metabolism; pathology
- From: Journal of Southern Medical University 2010;30(4):731-733
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of interleukin 18 (IL-18) and prostaglandin E2 (PGE2) and their relationship in the synoviocytes of patients with osteoarthritis (OA).
METHODSThe synovial tissues were obtained from 30 OA patients to isolate the synoviocytes for primary culture. The concentrations of IL-18 and PGE2 in the supernatants of synoviocyte culture were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTSThe concentration of IL-18 averaged 51.559-/+27.614 pg/ml and PGE2 327.036-/+333.561 pg/ml in the supernatant of the synoviocytes. A significant positive correlation was noted between their expressions (r=0.863, P<0.01).
CONCLUSIONIL-18 may induce the production of PGE2, and their interactions they may play an important role in the pathogenesis of OA.
