Effect of Kidney-Tonifying and Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in aged patients with kidney deficiency and blood stasis syndrome.
- Author:
Jian HU
1
;
Ming-hui YANG
;
Xin-li DENG
;
Jun-zhang LU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Aging; drug effects; CD11b Antigen; blood; CD18 Antigens; blood; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Kidney Diseases; drug therapy; metabolism; Leukocytes; metabolism; Male; Middle Aged; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; blood; bcl-2-Associated X Protein; blood
- From: Journal of Southern Medical University 2010;30(4):760-762
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Kidney-Tonifying plus Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in elderly patients with kidney deficiency and blood stasis syndrome.
METHODSSixty elderly patients with kidney deficiency and blood stasis syndrome were randomized into two groups. Patients in the treatment group received Kidney-Tonifying plus Blood-Promoting Recipe, and those in the control group receive no treatment. The expression of CD11b/CD18, Bcl-2/Bax, D-Dimeride, CD62p, PAC-I and the rate of platelet aggregation in peripheral blood leukocytes before and after the treatment were examined using flow cytometry in both groups.
RESULTSThe Recipe significantly decreased the levels of CD11b/CD18, D-Dimeride, CD62p, PAC-I and the rate of platelet aggregation (P<0.01), and increased the levels of Bcl-2/Bax (P<0.01).
CONCLUSIONKidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 and Bcl-2/Bax expression in blood leukocytes and improves microcirculatory status, which can be one of the mechanisms underlying its therapeutic effect in elderly patients.
