Preparation of paclitaxel-loaded polybutylcyanoacrylate nanoparticles.
- Author:
Ru-da CHEN
1
;
Fei REN
;
Guo-feng LI
;
Si-jia LIU
Author Information
- Publication Type:Journal Article
- MeSH: Delayed-Action Preparations; chemical synthesis; Drug Carriers; chemistry; Drug Delivery Systems; Enbucrilate; chemistry; Nanoparticles; chemistry; Paclitaxel; administration & dosage; Polymerization
- From: Journal of Southern Medical University 2010;30(4):763-766
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of different preparation methods on the encapsulation efficiency (EE) and drug loading (DL) of paclitaxel-loaded polybutylcyanoacrylate nanoparticles (PTX-PBCA-NPs) and optimize the preparation of PTX-PBCA-NPs.
METHODSWith DL and EE as the major indexes, the qualities of PTX-PBCA-NPs produced by the interfacial polymerization and emulsion polymerization method were compared. The optimized prescription was obtained by orthogonal design.
RESULTSThe ranges of EE of PTX-PBCA-NPs with the two methods were both 94.39%-99.23%. The highest DL with interfacial polymerization was (1.07-/+0.03)%, as compared to (0.86-/+0.01)% with emulsion polymerization. The optimized preparation conditions resulted in the mean size of PTX-PBCA-NPs of 235.6 nm, DL of 0.80%, and EE of 95.71%.
CONCLUSIONThe EE of PTX-PBCA-NPs prepared by the above two methods is consistent with the requirement of the Pharmacopoeia of China, and PTX-PBCA-NPs containing higher DL can be obtained via interfacial polymerization.
