Mobilization of Peripheral Blood Stem Cells with High Dose Cyclophosphamide Combination Chemotherapy and G-CSF in Breast Cancer Patients
- Author:
Shikai WU
1
;
Santai SONG
;
Xiaoqing LIU
;
Zefei JIANG
;
Anwen YAN
;
Wenhu WANG
;
Jingxin YU
;
Yimei QU
Author Information
1. Department of Breast Cancer, Affiliated Hospital of the Academy of Military Medical Sciences, 100039 Beijing, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2000;8(4):295-298
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effect of mobilization of peripheral blood stem cells (PBSC) with high dose cyclophosphamide combination chemotherapy and G-CSF in breast cancer patients, a new mobilization protocol was designed on the basis of standard combination chemotherapy regimen, in which the dose of cyclophosphamide was raised to 2 to 4 times, and G-CSF began to be used at the dose of 150 micro g twice everyday when white blood cell (WBC) decreased below 1.0 x 10(9)/L. PBSC collection was performed while WBC increased over 5.0 x 10(9)/L during bone marrow recovering. The PBSC mobilization protocol was completed in 10 patients, the median nadir of WBC was 0.8 (0.4 - 1.0) x 10(9)/L, the median time of PBSC collection was 2 (2 - 4), the median number of collected CD34(+) cells was 6.43 (1.99 - 8.75) x 10(6)/kg. The results showed that the protocol, high dose cyclophosphamide combination chemotherapy, was an optimal PBSC mobilization regimen in breast cancer patients.
