Preliminary Study on the Effects of Novel Retinoids SX-115 and CHU-012 on NB4 Cell Line
- Author:
Yiyun YAO
1
,
2
,
3
,
4
;
Guanlin SUN
;
Zongru GUO
;
Weili WU
;
Yun WANG
;
Hui SU
Author Information
1. Ruijin Hospital, Shanghai Institute of Hematology, Shanghai Second Medical University, Shanghai 200025, China
2. The 9th People's Hospital, Shanghai Second Medical University, Shanghai 200000, China
3. Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China
4. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2000;8(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
In this research, the effects of two new retinoids, SX-115 and CHU-012, on promyelocytic leukemia cell line NB4 were studied in vitro. Cell proliferation, cell morphologic characters, cell cycle kinetics, reduction ability of NBT, differentiation antigens, immunofluorescence staining and RT-PCR were adopted as the observational parameters. The results showed that SX-115 and CHU-012 induced differentiation of NB4 cells at concentration of 10(-6) mol/L. Comparing the effects of the two retinoids with all trans-retinoic acid (ATRA) at same concentration, there was no significant difference among the three agents. The mechanism of the 2 new retinoids remains possibly the same as ATRA.
