The Feature of Skewing Distribution of TCR Vbeta T Cells from Peripheral Blood and Bone Marrow in Patients with AML-M(5)
- Author:
Lijian YANG
1
,
2
;
Yangqiu LI
;
Shaohua CHEN
;
Mingfang QI
;
Yuhong LU
;
Gengxin LUO
Author Information
1. Department of Hematology, Medical College, Jinan University, Guangzhou 510632, China
2. Deptartment of Hematology, The First Affiliated Hospitol of Medical College, Jinan University, Guangzhou 510632, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2000;8(3):196-198
- CountryChina
- Language:Chinese
-
Abstract:
The TCR Vbeta 24 subfamily genes were amplified in peripheral blood and bone marrow mononuclear cells from 5 cases with acute monocytic leukemia (AML-M(5)) using RT-PCR, to observe the distribution of TCR Vbeta subfamilies. The results indicated that 1 - 19 Vbeta subfamily T cells could be identified in different samples from AML-M(5) cases. The variation of distribution of TCR Vbeta subfamily T cells could be found in different individual samples. The results provided the feature of cell immune function change in skewed distribution of TCR Vbeta subfamily T cells from peripheral blood and bone marrow of patients with AML-M(5).
