Therapeutic Effect of rhIL-11 on Thrombocytopenia Induced by Carboplatin in Rhesus Monkeys
- Author:
Qiujun LU
1
;
Liqing WEN
;
Shaoming GUO
;
Zhe SUN
;
Yuanyuan CHEN
;
Yuanmin LI
;
Yue GAO
;
Bo DONG
;
Weijing LIU
Author Information
1. Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2000;8(2):129-132
- CountryChina
- Language:Chinese
-
Abstract:
The effectiveness of rhIL-11 on thrombocytopenia induced by carboplatin in rhesus monkeys was investigated. Thrombocytopenia was induced in monkeys by i.v. administration of carboplatin at a dose of 15 mg/kg(-1)/d(-1) for three consecutive days. rhIL-11 (50 or 100 micro g/kg(-1)/d(-1)) or Neumega (100 micro g/kg(-1)/d(-1)) were administered s.c. for 14 days beginning one day following the final dose of carboplatin. The results showed that rhIL-11 significantly improved mean platelet nadirs and shortened the mean duration of platelet counts less than 50% of pre-treatment values. Administration of rhIL-11 also resulted in moderate increase of the reticulated platelet, leukocyte and reticulocyte counts in peripheral blood and megakaryocytic and erythroid progenitors in bone marrow. rhIL-11 did not enhance ADP-induced platelet aggregation. These results indicate that rhIL-11 has a potent thrombopoietic effect in vivo and could be an important agent to reduce the severity and duration of thrombocytopenia following chemotherapy.
