Hypermethylation status of blu gene in nasopharyngeal lymphoma.
- Author:
Xiao-hua ZHANG
1
;
Fen JIANG
;
Min LI
;
Qing XU
;
Ning LI
;
Qian TAO
;
Zi-fen GAO
Author Information
- Publication Type:Journal Article
- MeSH: DNA Methylation; Genes, Tumor Suppressor; Humans; Lymphoma; genetics; pathology; Nasopharyngeal Neoplasms; genetics; pathology; Polymerase Chain Reaction; methods; Tumor Suppressor Proteins
- From: Chinese Journal of Hematology 2003;24(3):138-140
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the hypermethylation status of blu gene promoter in nasopharyngeal NK/T cell lymphoma and its role in the tumorigenesis and molecular diagnosis of this lymphoma.
METHODSTwenty cases of paraffin-embedded nasopharyngeal NK/T cell lymphomas tissues were studied by using methylation specific PCR (MSP).
RESULTSHypermethylation of blu gene promoter is detected in 6 of 20 (30%) nasopharyngeal NK/T cell lymphoma. The 6 positive cases were 4 in 15 nasopharyngeal NK cell lymphomas, 1 of 2 NK like T cell lymphoma and 1 in 3 peripheral T cell lymphomas (unspecified type).
CONCLUSIONHypermethylation of blu gene promoter in nasopharyngeal NK/T cell lymphoma indicated the inactivation of blu gene and its possible role in the tumorigenesis of this lymphoma. blu gene methylation could be detected in paraffin-embedded tissue and used as a new molecular marker for the diagnosis of this lymphoma.
