Clinical and laboratory studies on childhood acute leukemia with 11q23 abnormalities.
- Author:
Ya-xiang HE
1
;
Yong-quan XUE
;
Jun HE
;
Xue-lan ZHANG
;
Zheng-hua JI
;
Yi-ping HUANG
;
Xue-ming ZHU
;
Hai-long HE
;
Yi-huan CHAI
;
Ling-li ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, Pair 11; genetics; Cytogenetic Analysis; Female; Humans; Immunophenotyping; Infant; Leukemia; drug therapy; genetics; immunology; Male; Prognosis; Retrospective Studies
- From: Chinese Journal of Hematology 2003;24(7):358-361
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the interrelations among morphology, immunology, cytogenetics and clinical outcome in childhood acute leukemia with 11q23 abnormalities.
METHODSEighteen patients with 11q23 abnormalities, from 320 childhood acute leukemia patients, were retrospectively analysed for cell morphology, flow cytometry, immunophenotyping, R-banding karyotype as well as clinical features and prognosis. Twenty cases of childhood AL with normal karyotype during the same period were used as control.
RESULTSThe incidence of 11q23 abnormalities in our childhood acute leukemia patients was 5.63% including 14 acute lymphoblastic leukemia (ALL) and 4 acute myeloid leukemia (AML). Of 16 cases immunophenotypically tested, 13 expressed lymphoid antigens and 3 CD(34) and other myeloid antigens. Karyotype analysis disclosed the following abnormalities: t(4; 11)(q21; q23) in 6 cases, t(10; 11)(p13; q23) in 3, t(11; 19)(q23; p13) in one and del(11)(q23) in 6. The complete remission rate for these patients with 11q23 abnormalities was comparable to that of the control (72.2% vs 80.0%, P > 0.05), while the mortality rate in the former was significantly higher than that in the latter (61.1% vs 25.0%, P < 0.05).
CONCLUSIONS11q23 abnormalities were mainly seen in childhood ALL and acute monocytic leukemia with unique prognostic features.
