The clinical features of severe aplastic anemia patients with complication of infection.
- Author:
Yu-hong WU
1
;
Zong-hong SHAO
;
Hong LIU
;
Zhen-zhu CUI
;
Tie-jun QIN
;
Rong FU
;
Guang-sheng HE
;
Jun SHI
;
Jie BAI
;
Yan-ran CAO
;
Tian-ying YANG
;
Chong-li YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Anemia, Aplastic; complications; Anti-Bacterial Agents; therapeutic use; Bacteria; isolation & purification; Child; Child, Preschool; Female; Humans; Infant; Infection; drug therapy; etiology; Male; Middle Aged; Time Factors
- From: Chinese Journal of Hematology 2003;24(10):530-533
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical features of severe aplastic anemia (SAA) patients with complication of infection.
METHODSA retrospective analysis of prevalence of infection occurring in 229 SAA patients, their bacterial spectrum, and the effect of GM-CSF or G-CSF on the infection were done.
RESULTThe prevalence of infection in SAA patients was 86.0%, among which 54.2% was infected with gram-positive organisms, 40.0% with gram-negative bacilli and 5.8% with fungal infections. Septicemia occurred mostly with E. coli and Pseudomonas infection. Patient's neutropenia was significantly related to the infection. The patients with neutrophil count less than 0.2 x 10(9)/L had more frequent and severe infection. Age, hemoglobin level, subtype of T lymphocytes and antithymocyte globulin therapy were not related to infection. Prophylaxis usage of floxacin could not reduce patient' gastrointestinal infection. The total mortality of SAA patients with infection was 23.1%. Pulmonary infection and septicemia increased mortality, and GM-CSF/G-CSF therapy reduce mortality.
CONCLUSIONSAA patients were at high risk of infection which was significantly associated with severe neutropenia. GM-CSF or G-CSF therapy exerts an assistant role to antibiotics in controlling the infections.
