Semen-derived enhancer of viral infection--a key factor in sexual transmission of HIV.
- Author:
Jiang-Man DUAN
1
;
Jia-Yin QIU
;
Sui-Yi TAN
;
Shu-Wen LIU
;
Lin LI
Author Information
1. First School of Clinical Medical Sciences, Guangzhou 510515, China. duanjm88626@gmail.com
- Publication Type:Journal Article
- MeSH:
HIV Infections;
etiology;
transmission;
Humans;
Male;
Semen;
physiology;
Sexually Transmitted Diseases, Viral;
etiology;
Static Electricity
- From:
Chinese Journal of Virology
2012;28(1):84-88
- CountryChina
- Language:Chinese
-
Abstract:
Semen-derived enhancer of viral infection(SEVI) is a peptide fragment (PAP248-286) from prostatic acid phosphatase(PAP), which can enhance human immunodeficiency virus infection. The mechanisms of SEVI include: (1) SEVI with several cationic amino acid residues reduced electrostatic repulsion between HIV virus and the target cells; (2) The disorder state of SEVI in the human body fluids was helpful to the interaction between virus and the target cell membranes; (3) SEVI could capture HIV particles directly and speed the velocity of virus on the surface of the target cells and improve adsorption and fusion. Currently, the substances of inhibiting SEVI activity include: EGCG from green tea, small molecule compound of aminoquinoline Surfen, ThT analogs BTA-EG6. Those compounds might block the combination of HIV and SEVI or prevent the formation of amyloid fibers, and then reduce the enhancement of SEVI. The studies on the biological characteristics and mechanisms of SEVI have a big benefit for the prevention and treatment of HIV infection.
