Molecular characteristics and immune evasion strategies of ORFV: a review.
- Author:
Yong-Zhong YU
1
;
Zhi-Jun WU
;
Zhan-Bo ZHU
;
Qiu-Zhen PAN
;
Yu-Dong CUI
Author Information
1. College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, China. yyz1968@126.com
- Publication Type:Journal Article
- MeSH:
Animals;
Ecthyma, Contagious;
immunology;
virology;
Gene Expression Regulation, Viral;
Immune Evasion;
Orf virus;
genetics;
immunology;
Viral Proteins;
genetics;
immunology
- From:
Chinese Journal of Virology
2012;28(3):278-284
- CountryChina
- Language:Chinese
-
Abstract:
Contagious ecthyma (also known as orf) is an acute skin zoonosis caused by orf virus (ORFV), which affects sheep, goats and humans. As one of the typical species of the Parapoxvirus genus of the Poxviridae family, orf virus has distinctive and unique characteristics of these species. A range of immuno-modulatory/pathogenesis -related genes acquired by virus that function is to limit (at least transiently) the effectiveness of host immunity during its evolution. This review is aimed to describe the latest progress on the molecular characteristics of ORFV, and upon which we analyzed molecular mechanism of the immune escape designed and a set of strategies developed for ORFV to effective against immune clearance of the host. Known as an essential component in evolutionary system, host is regulated by ORFV for using in population evolution. By the ORFV evolutional immune regulation components and its effect approach, we can understand the viral biological characteristics of ORFV, and it is helpful for us to further study the counter-measures of this disease.
