The research progress of foamy virus Bet protein.
- Author:
Yuan GAO
1
;
Yan SUN
;
Zhi LI
;
Qing-Mei LIU
;
Wan-Hong LIU
;
Xiao-Hua HE
Author Information
1. College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China. gaoyuan033@stu.snnu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Gene Expression Regulation, Viral;
Humans;
Retroviridae Infections;
immunology;
virology;
Retroviridae Proteins;
genetics;
metabolism;
Spumavirus;
genetics;
metabolism
- From:
Chinese Journal of Virology
2012;28(3):285-290
- CountryChina
- Language:Chinese
-
Abstract:
Foamy virus can establish lifelong persistent infection in mammal hosts without inducing diseases. Such special characteristic stimulates the interests of researchers. As reported, the accessory protein Bet of foamy virus could regulate the gene expression and infection cycle of foamy virus and take part in the generation of chronic viral infection. And also, Bet might prevent the host cellular defense factor APO-BEC3 from interfering the replication of virus and play a role in maintaining viral persistent infection. In order to elucidate the roles of Bet in the foamy virus replication and infection, this review summarized the research progress of Bet protein reported in recent years.