Hepatitis B virus core antigen as a carrier for virus-like partical vaccine: a review.
- Author:
Xing-Yu YANG
1
;
Hong BO
;
Yue-Long SHU
Author Information
1. World Health Orgnization Global Influenza Collaboration, Centre for Reference and Reaserch, State Key Laboratory for Molecular Virology and Genetic Enginering, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing 102206, China. yangxingyu@cnic.org.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Defective Viruses;
genetics;
immunology;
Gene Expression;
Hepatitis B Core Antigens;
genetics;
immunology;
Humans;
Vaccines;
genetics;
immunology
- From:
Chinese Journal of Virology
2012;28(3):311-316
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus core antigen (HBcAg) is a major viral nucleocapsid protein of HBV. It is a 21-22kD protein consisting of 183-185 amino acids. Because of its easy purification, strong immunogenicity, high expression level, and self-assembles into the virus-like particles (VLP), HBcAg could be an efficient and safe VLP carrier for developing vaccines for various pathogens. Up to now, HBcAg VLP carrier has been an important system to develop novel vaccines and many antigen epitope genes from viruses, bacteria and parasites were expressed successfully using the system.
