Comparison between different gene and near full-length genome on the phylogenetic analyses of HIV-1 subtype B' in China.
- Author:
Zhe LI
1
;
Yao YANG
;
Jing WEI
;
Yi FENG
;
Hui XING
;
Xiang HE
;
Yi-Ming SHAO
Author Information
1. State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- MeSH:
Amino Acid Sequence;
China;
epidemiology;
Cluster Analysis;
Genes, Viral;
genetics;
HIV-1;
classification;
genetics;
Molecular Epidemiology;
Molecular Sequence Data;
Phylogeny;
pol Gene Products, Human Immunodeficiency Virus;
chemistry;
genetics
- From:
Chinese Journal of Virology
2012;28(4):366-371
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to compare the influence of different genes to the results of HIV-1 subtype B' phylogenetic analyses. We first split 47 near full-length genome sequences of subtype B' into different regions (gag, pol, vif, vpr, vpu, env, nef), which derived from various risk populations and geographic regions from Thailand, Myanmar and China from published studies. Phylogenetic analyses were performed to each region obtained. The phylogenetic results of different regions were compared to that of the near full-length genome sequences. The pol gene was found to have the lowest diversity and evolutionary rate, and could repeat the phylogenetic results by using near full-length genome sequences. Although the env gene has the highest diversity and evolutionary rate, it could not achieve the similar results. This study compared the influence to the results of HIV-1 subtype B' phylogenetic analyses by using different genes and laid foundation for further molecular survey and analyses of the transmission of subtype B' in China.
