Expressions and significance of B7-H1 and programmed death-1 in lymphocytes from patients with chronic hepatitis B virus infection.
- Author:
Yong-gang LI
1
;
Liang-en CHEN
;
Guo-feng CHEN
;
Fu-sheng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antigens, CD; metabolism; B7-H1 Antigen; Case-Control Studies; Dendritic Cells; metabolism; Female; Hepatitis B, Chronic; metabolism; Humans; Male; Middle Aged; T-Lymphocytes; metabolism; Young Adult
- From: Chinese Journal of Hepatology 2007;15(10):738-741
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the expressions of B7-H1 and its receptor programmed death-1 (PD-1) on circulating T cells and myeloid dendritic cells (mDCs) in patients with chronic hepatitis B virus (HBV) infection and to investigate the correlation between their expressions and their disease status.
METHODSThe expressions of B7-H1 and PD-1 on mDCs and T lymphocytes in 30 patients with chronic HBV infection and 28 healthy controls were analyzed by a fluorescence-activated cell sorter (FACS). Real time-polymerase chain reaction (RT-PCR) was used to measure the serum HBV DNA load.
RESULTSBoth B7-H1 and PD-1 were significantly upregulated on T cells and mDCs in those patients. Their expressions were positively correlated with the patients serum ALT levels and HBV DNA loads.
CONCLUSIONB7-H1 and PD-1 expressions in our patients with chronic hepatitis B are closely associated with their disease status.
