A clinical analysis of HBV reactivation in patients with malignant tumors.
- Author:
Li-Na MA
1
;
Gui-Zhen SUN
;
Jin-Ling DONG
;
Chun-Yang HUANG
;
Xin-Yue CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Combined Chemotherapy Protocols; adverse effects; Antiviral Agents; therapeutic use; Carrier State; virology; Female; Hepatitis B; virology; Hepatitis B virus; drug effects; Humans; Lamivudine; therapeutic use; Male; Neoplasms; drug therapy; virology; Virus Activation; drug effects
- From: Chinese Journal of Hepatology 2007;15(11):809-811
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the anti-viral therapy effect on HBV reactivation in malignant tumor patients and hepatitis B virus carriers after their cancer chemotherapy.
METHODSThirteen cancer patients but also chronic hepatitis B virus carriers were enrolled in this study. They were randomly put into two groups. Eight patients were put in the therapeutic group. They all had abnormal liver functions induced by the reactivation of HBV after their cancer chemotherapy. Then they were treated with lamivudine. The other 5 cases were treated with lamivudine before their cancer chemotherapy when their serum HBV DNA levels were less than 10(3) copies/ml (preventive therapeutic group). The two groups were followed-up with liver function tests and serum HBV DNA level measurements.
RESULTSAmong the 8 cases of the therapeutic group, 5 cases died of liver failure; cancer chemotherapy was postponed or even terminated in 3 patients due to liver function abnormality and anti-virus treatment was started. In the preventive therapy group, no HBV reactivation was observed in any of the 5 cases.
CONCLUSIONFor HBV carrier cancer patients, an anti-viral therapy before their cancer chemotherapy seems to be very important.
