A novel azo-type compound from Dendrolobium triangulare.
- Author:
Qian-Jun ZHANG
1
;
Xiao-Sheng YANG
;
Hai-Yan ZHU
;
Qian-Yun SUN
;
Xiao-Jiang HAO
Author Information
1. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Azo Compounds;
isolation & purification;
pharmacology;
Fabaceae;
chemistry;
PC12 Cells;
Rats
- From:
Acta Pharmaceutica Sinica
2009;44(9):1009-1013
- CountryChina
- Language:Chinese
-
Abstract:
Thirteen compounds from Dendrolobium triangulare (Retz.) Schindl. were isolated and purified by chromatography on silica gel, macroporous resin column and recrystallization method, and their structures were elucidated by chemical and spectral analyses as azo-2, 2'-bis [Z-(2, 3-dihydroxy-4-methyl-5-methoxy) phenyl ethylene] (1), beta-sitosterol (2), N-(2'-hydroxy-tetracosanoyl)-2-amino-1, 3, 4-trihydroxyoctadec-8E-ene (3), lupeol (4), cycloeucalenol (5), daucosterol (6), betulinc acid (7), betulin (8), glyceryl hexacosanoate (9), glyceryl 26-hydroxy hexacosanoate (10), methyl pheophorbide-a (11), acacetin-7-O-alpha-L-rhamnopyranosyl (1-6)-beta-D-glucopyranoside (12) and robinin (13). To our knowledge, all compounds are obtained from Dendrolobium genus for the first time and compound 1 is a novel compound. Moreover, it is understood that compound 1 has better protection against PC12 cell damnification deduced by glutamate, than that of Vitamin E in 2 microg x mL(-1) concentration.
