Comparison of the Framingham Risk Score, UKPDS Risk Engine, and SCORE for Predicting Carotid Atherosclerosis and Peripheral Arterial Disease in Korean Type 2 Diabetic Patients.
10.4082/kjfm.2011.32.3.189
- Author:
Hye Ran AHN
1
;
Min Ho SHIN
;
Woo Jun YUN
;
Hye Yeon KIM
;
Young Hoon LEE
;
Sun Seog KWEON
;
Jung Ae RHEE
;
Jin Su CHOI
;
Seong Woo CHOI
Author Information
1. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
- Publication Type:Original Article
- Keywords:
Risk Assessment;
Peripheral Arterial Disease;
Carotid Artery Thrombosis;
Diabetes Mellitus, Type 2
- MeSH:
Ankle Brachial Index;
Area Under Curve;
Carotid Artery Diseases;
Carotid Artery Thrombosis;
Carotid Intima-Media Thickness;
Coronary Disease;
Diabetes Mellitus, Type 2;
Great Britain;
Humans;
Odds Ratio;
Peripheral Arterial Disease;
Risk Assessment
- From:Korean Journal of Family Medicine
2011;32(3):189-196
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: To compare the predictability of the Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study (UKPDS) risk engine, and the Systematic Coronary Risk Evaluation (SCORE) for carotid atherosclerosis and peripheral arterial disease in Korean type 2 diabetic patients. METHODS: Among 1,275 registered type 2 diabetes patients in the health center, 621 subjects with type 2 diabetes participated in the study. Well-trained examiners measured the carotid intima-media thickness (IMT), carotid plaque, and ankle brachial index (ABI). The subject's 10-year risk of coronary heart disease was calculated according to the FRS, UKPDS, and SCORE risk scores. These three risk scores were compared to the areas under the curve (AUC). RESULTS: The odds ratios (ORs) of all risk scores increased as the quartiles increased for plaque, IMT, and ABI. For plaque and IMT, the UKPDS risk score provided the highest OR (95% confidence interval) at 3.82 (2.36, 6.17) and at 6.21 (3.37, 11.45). For ABI, the SCORE risk estimation provided the highest OR at 7.41 (3.20, 17.18). However, no significant difference was detected for plaque, IMT, or ABI (P = 0.839, 0.313, and 0.113, respectively) when the AUCs of the three risk scores were compared. When we graphed the Kernel density distribution of these three risk scores, UKPDS had a higher distribution than FRS and SCORE. CONCLUSION: No significant difference was observed when comparing the predictability of the FRS, UKPDS risk engine, and SCORE risk estimation for carotid atherosclerosis and peripheral arterial disease in Korean type 2 diabetic patients.
