Two new phenolic acids from Drynariae rhizoma.
- Author:
Yong-hong LIANG
1
;
Min YE
;
Ling-zhi ZHANG
;
Hui-fang LI
;
Jian HAN
;
Bao-rong WANG
;
De-an GUO
Author Information
1. The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Benzoates;
chemistry;
isolation & purification;
Caffeic Acids;
chemistry;
isolation & purification;
Cinnamates;
chemistry;
isolation & purification;
Gallic Acid;
chemistry;
isolation & purification;
Glycerol;
analogs & derivatives;
chemistry;
isolation & purification;
Hydroxybenzoates;
chemistry;
isolation & purification;
Imines;
chemistry;
isolation & purification;
Lauric Acids;
chemistry;
isolation & purification;
Molecular Conformation;
Molecular Structure;
Parabens;
chemistry;
isolation & purification;
Plants, Medicinal;
chemistry;
Polypodiaceae;
chemistry;
Rhizome;
chemistry
- From:
Acta Pharmaceutica Sinica
2010;45(7):874-878
- CountryChina
- Language:Chinese
-
Abstract:
To study the chemical constituents of Drynariae Rhizoma, nine phenolic acids were isolated from a 70% ethanol extract by using a combination of various chromatographic techniques including column chromatography over silica gel, ODS, Sephadex LH-20, and semi-preparative HPLC. By spectroscopic techniques including 1H NMR, 13C NMR, 2D NMR, and HR-ESI-MS, these compounds were identified as 4, 4'-dihydroxy-3, 3'-imino-di-benzoic acid (1), protocatechuic acid (2), gallic acid (3), p-hydroxybenzoic acid (4), (E)-caffeic acid (5), ethyl trans-3, 4-dihydroxycinnamate (6), caffeic acid 4-O-beta-D-glucopyranoside (7), p-coumaric acid 4-O-beta-D-glucopyranoside (8), and 23(S)-12-O-caffeoyl-12-hydroxyllauric acid glycerol ester (9), separately. Among them, 1 and 9 are new compounds, and 3, 4, and 6 were isolated from Drynaria species for the first time.
