Recent advances in the study of accelerated blood clearance phenomenon of PEGylated liposomes.
- Author:
Huan XU
1
;
Kai-Qian WANG
;
Wei-Wei HUANG
;
Yi-Hui DENG
;
Da-Wei CHEN
Author Information
1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antibiotics, Antineoplastic;
administration & dosage;
pharmacokinetics;
Doxorubicin;
administration & dosage;
pharmacokinetics;
Drug Carriers;
Immunoglobulin M;
biosynthesis;
blood;
Liposomes;
administration & dosage;
blood;
pharmacokinetics;
Liver;
metabolism;
Metabolic Clearance Rate;
Particle Size;
Polyethylene Glycols;
administration & dosage;
metabolism;
pharmacokinetics;
Serum Albumin, Bovine;
pharmacokinetics;
Spleen;
immunology;
metabolism
- From:
Acta Pharmaceutica Sinica
2010;45(6):677-683
- CountryChina
- Language:Chinese
-
Abstract:
It is generally believed that liposomes modified with polyethylene glycol (PEG) have no or lower immunogenicity. However, based on many recent literatures, when the PEGylated liposomes were repeatedly applied to the same animal, the immune responses occurred. The first injection of PEGylated liposomes resulted in a reduction in the circulation time and an increase in hepatic and splenic accumulation of the second dose of PEGylated liposomes in a time-interval, which was called "accelerated blood clearance (ABC)" phenomenon. Such immunogenicity of PEGylated liposomes presents a barrier in the research of liposomal formulations and their use in the clinics. This review focused on the definition, the method of verification, the development of the reason for ABC phenomenon, influencing factors of ABC phenomenon, and discussed if other PEGylated nanocarriers also induce ABC phenomenon.
