Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders.
- Author:
Ning SHEN
1
;
Cai-Na LI
;
Yi HUAN
;
Zhu-Fang SHEN
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Berberine;
isolation & purification;
pharmacology;
Blood Glucose;
metabolism;
Coptis;
chemistry;
Diabetes Mellitus;
metabolism;
Drugs, Chinese Herbal;
isolation & purification;
pharmacology;
Humans;
Insulin;
metabolism;
secretion;
Insulin-Secreting Cells;
drug effects;
Metabolic Diseases;
metabolism;
Nicotinamide Phosphoribosyltransferase;
biosynthesis;
genetics;
Plants, Medicinal;
chemistry;
Protein Kinases;
metabolism;
RNA, Messenger;
metabolism;
Receptors, LDL;
genetics;
metabolism;
Signal Transduction
- From:
Acta Pharmaceutica Sinica
2010;45(6):699-704
- CountryChina
- Language:Chinese
-
Abstract:
Berberine, an isoquinoline alkaloid isolated from some Chinese medicinal herbs such as Coptidis rhizoma, has been used for the treatment of diarrhea and other gastrointestinal infections as an antibacterial drug in Chinese medicine. In recent years, it was reported to have beneficial effects on the metabolism disorders states of diabetes. The mechanisms involve many aspects of the diabetes, including regulating the blood cholesterol and triglyceride, lowering blood glucose, ameliorating the insulin resistant state and influencing the function of the pancreatic beta cell.
