Synthesis and activity of some new histone deacetylases inhibitors.
- Author:
Yong-Hao CHENG
1
;
Yan-Shen GUO
;
Hai-Zhu HAN
;
Nan WANG
;
Guo-Hong ZHANG
;
Zong-Ru GUO
;
Song WU
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
chemical synthesis;
chemistry;
pharmacology;
Biphenyl Compounds;
chemical synthesis;
chemistry;
pharmacology;
Histone Deacetylase Inhibitors;
chemical synthesis;
chemistry;
pharmacology;
Histone Deacetylases;
metabolism;
Mice;
Molecular Structure;
Phenylpropionates;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2010;45(6):735-741
- CountryChina
- Language:Chinese
-
Abstract:
To explore novel histone deacetylase (HDAC) inhibitors with anti-tumor activity, twelve target compounds were synthesized, and their structures were confirmed by 1H NMR, MS and elemental analyses. Evaluation results in vitro showed that compound Ia exhibited potent inhibition against HDAC and is worth for further investigation. And compounds IIa, IIb, IIIa-IIIi possessed moderate HDAC inhibitory activity.
