UPLC-Q-TOF/MS analysis of naringin and naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri grandis.
- Author:
Guo-Ling SUN
1
;
Da-Wei QIAN
;
Jin-Ao DUAN
;
Xiang-Ming LI
;
Jian-Yi WAN
Author Information
1. Nanjing University of Chinese Medicine, Nanjing 210046, China.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Chromatography, High Pressure Liquid;
Citrus;
chemistry;
Drugs, Chinese Herbal;
administration & dosage;
isolation & purification;
pharmacokinetics;
Feces;
chemistry;
Flavanones;
metabolism;
urine;
Male;
Plants, Medicinal;
chemistry;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- From:
Acta Pharmaceutica Sinica
2010;45(6):761-766
- CountryChina
- Language:Chinese
-
Abstract:
To analyze naringin, naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri Grandis, healthy SD rats were fed with alcohol extract of Exocarpium Citri Grandis for 3 days. On the last day, 0-24 h feces and 0-4 h, 4-8 h, 8-24 h urine were collected and analyzed by UPLC-Q-TOF/MS. The post-acquisition data were processed using Metabolynx The result is that naringin and its 6 metabolites, naringenin and its 4 metabolites were detected in the urine of rat. Meanwhile, naringin and its 3 metabolites, naringenin and its 2 metabolites were detected in the feces of rat.
